Conventional and microwave assisted synthesis of small molecule based biologically active heterocyclic amidine derivatives
IR@IIIM: CSIR-Indian Institute of Integrative Medicine, Jammu
View Archive Info| Field | Value | |
| Title |
Conventional and microwave assisted synthesis of small molecule based biologically active heterocyclic amidine derivatives
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| Creator |
Sondhi, Sham M.
Rani, Reshma Roy, Partha Agrawal, S.K. Saxena, A.K. |
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| Subject |
Chemical Sciences
Pharmacological Sciences |
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| Description |
Heterocyclic amidine derivatives have been synthesized by condensation of 2-cyanopyrazine, 4-cyanopyridine
and 2-cyanopyridine with furfurylamine, histamine, 1-(3-aminopropyl)imidazole, 4-picolylamine, 2-picolylamine, and tryptamine respectively, in the presence of sodium methoxide as well as via microwave irradiation in good yields. All these compounds were screened for anti-inflammatory and anticancer activities. At a dose of 50 mg/kg p.o. compounds 3a (36.6%), 3d (32%), 4d (31.0%) and 4e(33.8%) exhibited good anti-inflammatory activity, comparable to standard drug ibuprofen which showed
39% activity at 50 mg/kg p.o.
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| Date |
2010
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://iiim.csircentral.net/234/1/10.1016j.ejmech.2009.11.030.pdf
Sondhi, Sham M. and Rani, Reshma and Roy, Partha and Agrawal, S.K. and Saxena, A.K. (2010) Conventional and microwave assisted synthesis of small molecule based biologically active heterocyclic amidine derivatives. European Journal of Medicinal Chemistry, 45 (3). pp. 902-908. ISSN 02235234 |
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| Relation |
http://dx.doi.org/10.1016/j.ejmech.2009.11.030
http://iiim.csircentral.net/234/ |
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