Cytotoxic and apoptotic activities of novel amino analogues of boswellic acids
IR@IIIM: CSIR-Indian Institute of Integrative Medicine, Jammu
View Archive Info| Field | Value | |
| Title |
Cytotoxic and apoptotic activities of novel amino analogues of boswellic acids
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| Creator |
Shah, Bhahwal A.
Kumar, Ajay Gupta, Pankaj Sharma, Madhunika Sethi, Vijay K. Saxena, Ajit K. Singh, Jaswant Qazi, Ghulam N. Taneja, Subhash C. |
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| Subject |
Chemical Sciences
Pharmacological Sciences |
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| Description |
4-Amino analogues prepared from b-boswellic acid and 11-keto-b-boswellic acid, wherein the carboxyl group in ursane
nucleus was replaced by an amino function via Curtius reaction, displayed improved cytotoxicity than the parent molecules. The same molecules also exhibited apoptotic activity by inducing DNA fragmentation.
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| Date |
2007
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://iiim.csircentral.net/235/1/10.1016j.bmcl.2007.10.011.pdf
Shah, Bhahwal A. and Kumar, Ajay and Gupta, Pankaj and Sharma, Madhunika and Sethi, Vijay K. and Saxena, Ajit K. and Singh, Jaswant and Qazi, Ghulam N. and Taneja, Subhash C. (2007) Cytotoxic and apoptotic activities of novel amino analogues of boswellic acids. Bioorganic & Medicinal Chemistry Letters, 17 (23). pp. 6411-6416. ISSN 0960894X |
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| Relation |
http://dx.doi.org/10.1016/j.bmcl.2007.10.011
http://iiim.csircentral.net/235/ |
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