Arthrobacter sp.: a lipase of choice for the kinetic resolution of racemic arylazetidinone precursors of taxanoid side chains
IR@IIIM: CSIR-Indian Institute of Integrative Medicine, Jammu
View Archive Info| Field | Value | |
| Title |
Arthrobacter sp.: a lipase of choice for the kinetic resolution of racemic arylazetidinone precursors of taxanoid side chains
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| Creator |
Anand, Naveen
Kapoor, Munish Ahmad, Khursheed Koul, Surrinder Parshad, Rajinder Manhas, Kuldip S. Sharma, Rattan L. Qazi, Ghulam N. Taneja, Subhash C. |
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| Subject |
Chemical Sciences
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| Description |
The native strain of Arthrobacter sp. (MTCC 5125) bearing a lipase has been found to be the most effective in the kinetic resolution of racemic arylazetidinones for producing cis-(3R,4S)-3-acetoxy-1-(4-methoxyphenyl)-4-phenyl-2-azetidinone, cis-(3R,4R)-3-acetoxy-1-(4-methoxyphenyl)-4-(2-furanyl)-2-azetidinone, cis-(3R,4R)-3-acetoxy 1-(4-methoxyphenyl)-4-(2-thienyl)-2-azetidinone, and cis-3-acetoxy-4-(t-butyl)-2-azetidinone products. The resolved compounds, which were obtained in high enantiopurity are important intermediates of amino acid side chains of paclitaxel
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| Date |
2007
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://iiim.csircentral.net/221/1/10.1016j.tetasy.2007.04.031.pdf
Anand, Naveen and Kapoor, Munish and Ahmad, Khursheed and Koul, Surrinder and Parshad, Rajinder and Manhas, Kuldip S. and Sharma, Rattan L. and Qazi, Ghulam N. and Taneja, Subhash C. (2007) Arthrobacter sp.: a lipase of choice for the kinetic resolution of racemic arylazetidinone precursors of taxanoid side chains. Tetrahedron: Asymmetry, 18 (9). pp. 1059-1069. ISSN 09574166 |
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| Relation |
http://dx.doi.org/10.1016/j.tetasy.2007.04.031
http://iiim.csircentral.net/221/ |
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