Design, Synthesis, and Biological Testing of 4β-[(4-Substituted)-1,2,3-triazol-1-yl]podophyllotoxin Analogues as Antitumor Agents
IR@IIIM: CSIR-Indian Institute of Integrative Medicine, Jammu
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| Title |
Design, Synthesis, and Biological Testing of 4β-[(4-Substituted)-1,2,3-triazol-1-yl]podophyllotoxin Analogues as Antitumor Agents
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| Creator |
Reddy, Pitta B.
Paul, David V. Agrawal, Satyam K. Saxena, Ajit K. Kumar, Halmuthur M. S. Qazi, Ghulam N. |
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| Subject |
Chemical Sciences
Pharmacological Sciences |
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| Description |
A series of 4b-[(4-substituted)-1,2,3-triazol-1-yl]podophyllotoxin analogues have been synthesized
with high regio-selectivity by employing copper(I)-catalyzed 1,3-dipolar cycloaddition of 1-O-propargyl monosaccharides with C4b-azido podophyllotoxin and C4b-azido-49-O-demethyl podophyllotoxin.All the compounds were evaluated for their anticancer activity against a panel of six human cancer cell lines. Among these, 49-O-demethyl podophyllotoxin congeners are showing promising anticancer activity mainly against HCT-15 (colon) and DU-145 (prostate) cells.
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| Date |
2008
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://iiim.csircentral.net/237/1/10.1002ardp.200700116.pdf
Reddy, Pitta B. and Paul, David V. and Agrawal, Satyam K. and Saxena, Ajit K. and Kumar, Halmuthur M. S. and Qazi, Ghulam N. (2008) Design, Synthesis, and Biological Testing of 4β-[(4-Substituted)-1,2,3-triazol-1-yl]podophyllotoxin Analogues as Antitumor Agents. Archiv der Pharmazie, 341 (2). pp. 126-131. ISSN 03656233 |
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| Relation |
http://dx.doi.org/10.1002/ardp.200700116
http://iiim.csircentral.net/237/ |
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