Semi-synthetic analogs of pinitol as potential inhibitors of TNF-α cytokine expression in human neutrophils
IR@IIIM: CSIR-Indian Institute of Integrative Medicine, Jammu
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| Title |
Semi-synthetic analogs of pinitol as potential inhibitors of TNF-α cytokine expression in human neutrophils
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| Creator |
Bhat, Khurshid A.
Shah, Bhahwal A. Gupta, Kuldeep K. Pandey, Anjali Bani, Sarang Taneja, Subhash C. |
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| Subject |
Chemical Sciences
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| Description |
Semi-synthetic analogs of pinitol were subjected to screening by determining TNF-a expression in human neutrophils using flowcytometry. Among the tested compounds, three derivatives displayed more than 50% inhibition of TNF-a cytokine secretion in LPS induced stimulated neutrophils and can be considered as potent anti-inflammatory moieties.
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| Date |
2009
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://iiim.csircentral.net/339/1/10.1016j.bmcl.2009.02.050.pdf
Bhat, Khurshid A. and Shah, Bhahwal A. and Gupta, Kuldeep K. and Pandey, Anjali and Bani, Sarang and Taneja, Subhash C. (2009) Semi-synthetic analogs of pinitol as potential inhibitors of TNF-α cytokine expression in human neutrophils. Bioorganic & Medicinal Chemistry Letters, 19 (7). pp. 1939-1943. ISSN 0960894X |
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| Relation |
http://dx.doi.org/10.1016/j.bmcl.2009.02.050
http://iiim.csircentral.net/339/ |
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