Solvent free synthesis, anti-inflammatory and anticancer activity evaluation of tricyclic and tetracyclic benzimidazole derivatives
IR@IIIM: CSIR-Indian Institute of Integrative Medicine, Jammu
View Archive Info| Field | Value | |
| Title |
Solvent free synthesis, anti-inflammatory and anticancer activity evaluation of tricyclic and tetracyclic benzimidazole derivatives
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| Creator |
Sondhi, Sham M.
Rani, Reshma Singh, Jaiveer Roy, Partha Agrawal, S.K. Saxena, A.K. |
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| Subject |
Chemical Sciences
Pharmacological Sciences |
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| Description |
Heterocyclic benzimidazole derivatives 3a–h, 5a–c and 7a–d have been synthesized by condensation of succinic acid (1) homophthalic acid (4) and 2,3-pyrazinedicarboxlic acid (6) with various substituted diamines under microwave irradiation in good yields. Structures assigned to 3a–h, 5a–c and 7a–d are fully supported by spectral data. All these compounds were screened for anti-inflammatory and anticancer activities. At a dose of 50 mg/kg po compounds 3b (39.4%) and 3c (39.2%) exhibited anti-inflammatory
activity, comparable to standard ibuprofen which showed 39% activity at 50 mg/kg po and compound 7c exhibit good anticancer activity against ovary (IGR-OV-1), breast (MCF-7) and CNS(SF-295) human cancer cell lines.
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| Date |
2010
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://iiim.csircentral.net/343/1/10.1016j.bmcl.2010.01.147.pdf
Sondhi, Sham M. and Rani, Reshma and Singh, Jaiveer and Roy, Partha and Agrawal, S.K. and Saxena, A.K. (2010) Solvent free synthesis, anti-inflammatory and anticancer activity evaluation of tricyclic and tetracyclic benzimidazole derivatives. Bioorganic & Medicinal Chemistry Letters, 20 (7). pp. 2306-2310. ISSN 0960894X |
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| Relation |
http://dx.doi.org/10.1016/j.bmcl.2010.01.147
http://iiim.csircentral.net/343/ |
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