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Pyrrolo[2,1-c][1,4]benzodiazepine–anthraquinone conjugates. Synthesis, DNA binding and cytotoxicity

IR@IIIM: CSIR-Indian Institute of Integrative Medicine, Jammu

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Title Pyrrolo[2,1-c][1,4]benzodiazepine–anthraquinone conjugates. Synthesis, DNA binding and cytotoxicity
 
Creator Kamal, Ahmed
Ramu, R.
Khanna, G.B. Ramesh
Saxena, Ajit Kumar
Shanmugavel, M.
Pandita, Renu Moti
 
Subject Chemical Sciences
 
Description New pyrrolobenzodiazepine–anthraquinone hybrids have been designed and synthesized, found to effectively bind to DNA and also exhibit cytotoxicity against many cancer cell lines.
 
Date 2004
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://iiim.csircentral.net/324/1/10.1016j.bmcl.2004.07.036.pdf
Kamal, Ahmed and Ramu, R. and Khanna, G.B. Ramesh and Saxena, Ajit Kumar and Shanmugavel, M. and Pandita, Renu Moti (2004) Pyrrolo[2,1-c][1,4]benzodiazepine–anthraquinone conjugates. Synthesis, DNA binding and cytotoxicity. Bioorganic & Medicinal Chemistry Letters, 14 (19). pp. 4907-4909. ISSN 0960894X
 
Relation http://dx.doi.org/10.1016/j.bmcl.2004.07.036
http://iiim.csircentral.net/324/