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Terminalia chebula(fruit) prevents liver toxicity caused by sub-chronic administration of rifampicin, isoniazid and pyrazinamide in combination

IR@IIIM: CSIR-Indian Institute of Integrative Medicine, Jammu

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Title Terminalia chebula(fruit) prevents liver toxicity caused by sub-chronic administration of rifampicin, isoniazid and pyrazinamide in combination
 
Creator Tasduq, SA
Singh, K
Satti, NK
Gupta, DK
Suri, KA
Johri, RK
 
Subject Pharmacological Sciences
 
Description Terminalia chebula Gertn. (Combetraceae) is an important herbal drug in Ayurvedic pharmacopea. In the present study, a 95% ethanolic extract of T. chebula (fruit) (TC extract), which was chemically characterized on the basis of chebuloside II as a marker, was investigated for hepatoprotective activity against anti-tuberculosis (anti-TB) drug-induced toxicity. TC extract was found to prevent the hepatotoxicity caused by the administration of rifampicin (RIF), isoniazid (INH) and pyrazinamide (PZA) (in combination) in a sub-chronic mode (12 weeks). The hepatoprotective effect of TC extract could be attributed to its prominent anti-oxidative and membrane stabilizing activities. The changes in biochemical observations were supported by histological profile.
 
Date 2006
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://iiim.csircentral.net/361/1/10.1191%2D0960327106ht601oa.pdf
Tasduq, SA and Singh, K and Satti, NK and Gupta, DK and Suri, KA and Johri, RK (2006) Terminalia chebula(fruit) prevents liver toxicity caused by sub-chronic administration of rifampicin, isoniazid and pyrazinamide in combination. Human & Experimental Toxicology, 25 (3). pp. 111-118. ISSN 09603271
 
Relation http://dx.doi.org/10.1191/0960327106ht601oa
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