Trichosporon beigelli esterase (TBE): a versatile esterase for the resolution of economically important racemates
IR@IIIM: CSIR-Indian Institute of Integrative Medicine, Jammu
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| Title |
Trichosporon beigelli esterase (TBE): a versatile esterase for the resolution of economically important racemates
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| Creator |
Koul, Surrinder
Koul, Jawahir Lal Singh, Budh Kapoor, Munish Parshad, Rajinder Manhas, Kuldeep S. Taneja, Subhash C. Qazi, Ghulam N. |
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| Subject |
Chemical Sciences
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| Description |
A hydrolase producing strain Trichosporon beigelli esterase (TBE) isolated from local cottage cheese in its native form has displayed versatility and high efficacy in the kinetic resolution of a wide range of economically important substrates, which include racemic secondary alcohols, such as 1-(6-methoxy-2-naphthyl)ethanol (E � 316), 1-(3,4-methylenedioxyphenyl)ethanol and pentanol(E � 180 and 156 resp.), and alkyl esters of carboxylic acids such as ibuprofen (E � 340), 2-(benzylthio)propanoic acid
(E � 1000). In other substrates such as in the primary alcohol 2-(6-methoxy-2-naphthyl)propan-1-ol and carboxylic acids such as 2-(5-bromo-6-methoxy-2-naphthyl)propanoic acid, 2-(2-naphthyloxy)propanoic acid, and substituted 2-thiopropanoic acids, it displayed moderate to low selectivity. Commercial lipases such as CCL, PPL, and PSL were also used in the resolution of the substrates
for comparative studies.
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| Date |
2005
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://iiim.csircentral.net/365/1/10.1016j.tetasy.2005.07.009.pdf
Koul, Surrinder and Koul, Jawahir Lal and Singh, Budh and Kapoor, Munish and Parshad, Rajinder and Manhas, Kuldeep S. and Taneja, Subhash C. and Qazi, Ghulam N. (2005) Trichosporon beigelli esterase (TBE): a versatile esterase for the resolution of economically important racemates. Tetrahedron: Asymmetry, 16 (15). pp. 2575-2591. ISSN 09574166 |
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| Relation |
http://dx.doi.org/10.1016/j.tetasy.2005.07.009
http://iiim.csircentral.net/365/ |
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