Synthesis and biological evaluation of chalcones and their derived pyrazoles as potential cytotoxic agents
IR@IIIM: CSIR-Indian Institute of Integrative Medicine, Jammu
View Archive Info| Field | Value | |
| Title |
Synthesis and biological evaluation of chalcones and their derived pyrazoles as potential cytotoxic agents
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| Creator |
Bhat, B.A.
Dhar, K.L. Puri, S.C. Saxena, A.K. Shanmugavel, M. Qazi, G.N. |
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| Subject |
Chemical Sciences
Pharmacological Sciences |
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| Description |
A series of substituted chalcones and their corresponding pyrazoles were synthesized and evaluated for in vitro cytotoxic activity against a panel of human cancer cell lines. Out of 93 compounds screened, 8 compounds, 1s, 3i,j,n, 4i,j,n and 4s, showed marked activity. Compounds 4j,n and 4s were found to be the most promising in this study. SAR is also discussed.
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| Date |
2005
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://iiim.csircentral.net/350/1/10.1016j.bmcl.2005.03.121.pdf
Bhat, B.A. and Dhar, K.L. and Puri, S.C. and Saxena, A.K. and Shanmugavel, M. and Qazi, G.N. (2005) Synthesis and biological evaluation of chalcones and their derived pyrazoles as potential cytotoxic agents. Bioorganic & Medicinal Chemistry Letters, 15 (12). pp. 3177-3180. ISSN 0960894X |
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| Relation |
http://dx.doi.org/10.1016/j.bmcl.2005.03.121
http://iiim.csircentral.net/350/ |
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