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Synthesis and cytotoxic activity of some novel polycyclic γ-butyrolactones

IR@IIIM: CSIR-Indian Institute of Integrative Medicine, Jammu

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Title Synthesis and cytotoxic activity of some novel polycyclic γ-butyrolactones
 
Creator Ishar, M.P.S.
Raj, Tilak
Agrawal, Satyam Kumar
Saxena, A.K.
Singh, Lakhwinder
Singh, Rajinder
Bhella, Surinderjit Singh
 
Subject Chemical Sciences
Pharmacological Sciences
 
Description Baeyer–Villiger oxidation of 5-aryl-7,11,11-trimethyltricyclo[5.4.0.03,6]-undec-1-en-4-ones 4a–h by H2O2 and formic acid in methanol yields mixtures of 3b,7,7-trimethyl-3-phenyl-3,3a,3b,4,5,6,7,8a-octahydro- 1H-indeno-[1,2-c]furan-1-ones 8a–h and 3b,7,7-trimethyl-3-phenyl-3,3a,3b,4,5,6,7,8a-octahydro-1H-indeno-[1,2-c]furan-2-ones 9a–h in high yields. The obtained butyrolactones 8a–h display cytotoxic activity against a number of human cancer cells.
 
Date 2008
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://iiim.csircentral.net/353/1/10.1016j.bmcl.2008.07.095.pdf
Ishar, M.P.S. and Raj, Tilak and Agrawal, Satyam Kumar and Saxena, A.K. and Singh, Lakhwinder and Singh, Rajinder and Bhella, Surinderjit Singh (2008) Synthesis and cytotoxic activity of some novel polycyclic γ-butyrolactones. Bioorganic & Medicinal Chemistry Letters, 18 (17). pp. 4809-4812. ISSN 0960894X
 
Relation http://dx.doi.org/10.1016/j.bmcl.2008.07.095
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