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Layered double hydroxide: Inorganic organic conjugate nanocarrier for methotrexate

IR@CGCRI: CSIR-Central Glass and Ceramic Research Institute, Kolkata


Field	Value

Title	Layered double hydroxide: Inorganic organic conjugate nanocarrier for methotrexate

Creator	Chakraborty, Manjusha Dasgupta, Sudip Bose, Poulomi Misra, Akhilesh Mandal, Tapan Kumar Mitra, Manoj Chakraborty, Jui Basu, Debabrata

Subject	Processing Science

Description	Layered double hydroxide (LDH)-methotrexate (MTX) nanohybrids were successfully synthesized using ex situ and in situ processes. X-ray diffraction patterns of the synthesized nanopowders revealed that intercalated MTX molecules were stabilized in tilted longitudinal conformation into the hydroxide interlayer space. Two separate hydroxyl peaks were found in the FTIR spectra of LDH-MTX nanopowders suggesting successful intercalation of the MIX molecule into LDH matrix. The synthesized powders were further characterized using transmission electron microscopy (TEM) and selected area electron diffraction (SAED) pattern. HRTEM images showed an increase in interlayer spacing in hydrothermally crystallized LDH-MTX nanohybrids as compared to pristine LDH. The study showed that depending on the synthesis route used to synthesize LDH-MTX nanohybrid, its particle size as well as morphology can be varied at nano scale. (C) 2011 Elsevier Ltd. All rights reserved.

Publisher	Pergamon-Elsevier

Date	2011-06

Type	Article PeerReviewed

Format	application/pdf

Identifier	http://cgcri.csircentral.net/84/1/J_Phys_ChemSolids72(2011)779%E2%80%93783.pdf Chakraborty, Manjusha and Dasgupta, Sudip and Bose, Poulomi and Misra, Akhilesh and Mandal, Tapan Kumar and Mitra, Manoj and Chakraborty, Jui and Basu, Debabrata (2011) Layered double hydroxide: Inorganic organic conjugate nanocarrier for methotrexate. Journal of Physics and Chemistry of Solids, 72 (6). pp. 779-783. ISSN 0022-3697

Relation	http://cgcri.csircentral.net/84/