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In vivo response of porous hydroxyapatite and beta-tricalcium phosphate prepared by aqueous solution combustion method and comparison with bioglass scaffolds

IR@CGCRI: CSIR-Central Glass and Ceramic Research Institute, Kolkata

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Title In vivo response of porous hydroxyapatite and beta-tricalcium phosphate prepared by aqueous solution combustion method and comparison with bioglass scaffolds
 
Creator Ghosh, Samir K.
Nandi, Samit K.
Kundu, Biswanath
Datta, Someswar
De, Dipak K.
Roy, Sujit K.
Basu, Debabrata
 
Subject Processing Science
 
Description Pure hydroxyapatite (HAp) and a biphasic calcium phosphate [containing 90% of beta-tri-calcium phosphate (beta-TCP) and 10% HAp] were tailored through an aqueous solution combustion synthesis. Porous struts were prepared using all the powders along with bioglass, a known bioactive material, and subsequently characterized. Sterilized struts were implanted to the lateral side of radius bone of 24 black Bengal goats of either sex, in which a blank hole was left unfilled in a group of six specimens to act as control. The bone formation response of the three implanting materials in vivo has been studied using scanning electron microscope and histological analysis in contrast with positive controls. Push-out tests were used to assess the mechanical strength at the bone-biomaterial interface. It was observed that interfacial response was strongly dependent on combinations of different physical and chemical parameters. The surface of beta-TCP exhibited similar characteristics of bone and was distinct from those of intervening apatite layer of bioglass. Lower bone ingrowth and reduced strength was observed with HAp compared to beta-TCP/bioglass-based implants. Bone formation response of the Ca-P material varied according to the composition of the implanting material, which could be tailored through this novel synthesis. (C) 2007 Wiley Periodicals, Inc.
 
Publisher WILEY-LISS
 
Date 2008-07
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://cgcri.csircentral.net/324/1/J_Biomed_Mater_Res_86B_(2008)__217%2D227.pdf
Ghosh, Samir K. and Nandi, Samit K. and Kundu, Biswanath and Datta, Someswar and De, Dipak K. and Roy, Sujit K. and Basu, Debabrata (2008) In vivo response of porous hydroxyapatite and beta-tricalcium phosphate prepared by aqueous solution combustion method and comparison with bioglass scaffolds. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 86B (1). pp. 217-227. ISSN 1552-4981
 
Relation http://cgcri.csircentral.net/324/