An Unique Specificity Of a Sialic Acid Binding Lectin Achatininh, From the Hemolymph of Achatina Fulica Snail
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
An Unique Specificity Of a Sialic Acid Binding Lectin Achatininh, From the Hemolymph of Achatina Fulica Snail
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| Creator |
Mandal, Chitra
Basu, Sujata |
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| Subject |
Infectious Diseases and Immunology
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| Description |
A sialic acid-binding lectin, AchatininH , from the hemolymph of Achatina
fulica snail is found to be highly specific for V-0-acetyl sialic acid.
The binding specificity of AchatininH distinguishes it from other known
sialic-acid specific lectins which usually show a broader range of specificity
for sialic acid. It is even better than crab lectin which shows specificity
for both 4- and V-0-acetylated derivatives of sialic acid. This limited
specificity of AchatininH appear to account for the fact that it agglutinates
only rabbit, rat and guineapig erythrocytes which contain V-0-acetylated
sialic acid but not horse (mainly contain 4-0-acetylated sialic acid), human,
monkey, sheep, goat and chicken erythrocytes which contain either N-acetyl
or N-glycolyl neuraminic acid but no 0-acetylated derivatives. This finding
was further supported by the potent inhibition of hemagglutination by free
9-0-acetylated neuraminic acid and by several glyco sphingolipids of human
origin having 0-acetylated sialic acid.
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| Publisher |
Elsevier
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| Date |
1987
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/1424/1/BIOCHEMICAL_AND_BIOPHYSICAL_RESEARCH_COMMUNICATIONS__148(_2);_1987[11].pdf
Mandal, Chitra and Basu, Sujata (1987) An Unique Specificity Of a Sialic Acid Binding Lectin Achatininh, From the Hemolymph of Achatina Fulica Snail. Biochemical and Biophysical Research Communications, 148 (2). pp. 795-801. |
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| Relation |
http://dx.doi.org/10.1016/0006-291X(87)90946-6
http://www.eprints.iicb.res.in/1424/ |
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