Urea Stibamine: An Improved Method of Preparation and its Antileishmanial Activity
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Urea Stibamine: An Improved Method of Preparation and its
Antileishmanial Activity
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| Creator |
Mahato, Shashi B
Pal, Bikas C Khan, Smriti Ghosh , Ananta K Mukerji, Krishna Ghosh, Dilip K |
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| Subject |
Chemistry
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| Description |
Urea stibamine, developed by Brahmachari (1) as an effective antileishmanial
drug, was used extensively during the second and third decades of the present
century for the treatment of visceral leishmaniasis (Kala-azar). The drug was
responsible for saving the lives of countless patients in eastern India (2), although
the chemical nature of urea stibamine was never thoroughly understood. Ghosh
et al. (3) reported that the value of the antimony content varied from 20 to 43%
in different samples; therefore the toxicity test was performed batchwise. The
chemical reaction involved in the preparation of the drug was also not clear (2).
The present paper deals with an improved method for preparation of urea stibamine,
its chromatographic and spectroscopic properties, toxicity, and antileishmanial
activity.
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| Date |
1987
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/1425/1/BIOCHEMICAL_MEDICINE_AND_METABOLIC_BIOLOGY__38(_1);1987[24]47%2D56.pdf
Mahato, Shashi B and Pal, Bikas C and Khan, Smriti and Ghosh , Ananta K and Mukerji, Krishna and Ghosh, Dilip K (1987) Urea Stibamine: An Improved Method of Preparation and its Antileishmanial Activity. Biochemical Medicine and Metabolic Biology, 38 (1). pp. 47-56. |
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| Relation |
http://dx.doi.org/10.1016/0885-4505(87)90061-2
http://www.eprints.iicb.res.in/1425/ |
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