Effect of Erythropoietin on the Glucose Transport of Rat Etythrocytes and Bone Marrow Cells
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Effect of Erythropoietin on the Glucose Transport of Rat Etythrocytes and Bone Marrow Cells
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| Creator |
Ghosal, Jharna
Chakraborty, MunMun Biswas, Tuli Ganguly, Chayan K Dutta, A G |
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| Subject |
Cell Biology & Physiology
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| Description |
Modern studies on the structure of membranes have revealed that chain length
and extent of saturation of fatty acids of phospholipids influence membrane
permeability (1). Differences in permeabilities of glycerol, erythritol, urea, and
anions have been reported to be related to the membrane phospholipids (2).
Erythrocyte membrane permeability increases with a rise in phosphatidylcholine
content of the membrane lipids (3). These results suggest that the lipid environment
of the membrane transport proteins can affect transmembrane fluxes in erythrocytes.
Erythrocytes of different species which differ in lipid composition, particularly
having loosely bound phospholipids, exhibited a marked difference in their
permeability characteristics (4). In short, phospholipids in biological membranes
have been shown to modulate the permeability behavior of the erythrocyte membrane.
The role of erythropoietin (Ep) on the erythrocyte membrane is quite
clear from our recent studies (5-8). We have demonstrated that Ep not only
stimulates [14C]acetate incorporation into membrane lipids (6) but also alters the
fatty acid composition of the erythrocyte membrane as well as the ratio of
saturated to unsaturated fatty acids (7). This hormone also has an influence on
the exchange of cholesterol and phospholipid between erythrocyte and plasma
(8). In view of the above observations we were interested in studying the effect
of this hormone on the permeability of glucose in erythrocytes.
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| Date |
1987
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/1426/1/BIOCHEMICAL_MEDICINE_AND_METABOLIC_BIOLOGY_38(2)_134%2D141;1987[17].pdf
Ghosal, Jharna and Chakraborty, MunMun and Biswas, Tuli and Ganguly, Chayan K and Dutta, A G (1987) Effect of Erythropoietin on the Glucose Transport of Rat Etythrocytes and Bone Marrow Cells. Biomedical Medicine and Metabolic Biology, 38 (2). pp. 131-141. |
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| Relation |
http://dx.doi.org/10.1016/0885-4505(87)90072-7
http://www.eprints.iicb.res.in/1426/ |
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