Suppression of Liver Uptake of Orally Fed Liposomes by Injection (I.P.)of Dextran Sulfate 500.
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Suppression of Liver Uptake of Orally Fed
Liposomes by Injection (I.P.)of Dextran Sulfate 500.
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| Creator |
Das, Nirmalendu
Basu, Mukul Kumar Das, Manoj Kumar |
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| Subject |
Drug Development/Diagnostics & Biotechnology
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| Description |
125Iodine labelled human immunoglobulin-G encapsulated liposomes were
administered orally to rats. Distribution of radioactivity was checked in various tissues
and in portal blood. The effect of dextran sulfate (DS 500,000 m. wt., liver blockade
agent) injection (i.p.) on the liver uptake of liposomes and on the amount of liposomes
appearing in the portal blood from the gastrointestinal tract have been studied. An
increased amount of radioactivity was observed in the portal blood and the amount of
radioactivity in the liver decreased appreciably after injection of dextran sulfate. In
both the cases the action of dextran sulfate started 2 hours after injection and reached
maximum at 12 hour, falling slightly at 24 hour.
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| Publisher |
Kluwer
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| Date |
1987
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/1427/1/Bioscience_Reports%2C__7(_6);_1987[36].pdf
Das, Nirmalendu and Basu, Mukul Kumar and Das, Manoj Kumar (1987) Suppression of Liver Uptake of Orally Fed Liposomes by Injection (I.P.)of Dextran Sulfate 500. Bioscience Reports, 7 (6). pp. 465-470. |
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| Relation |
http://dx.doi.org/10.1007/BF01116502
http://www.eprints.iicb.res.in/1427/ |
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