In Vitro and In Vivo Effect of Chloropromazine, Imipramine and Lithium Chloride on Monoamine Oxidase Activity in Rat Brain Mitochondria
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
In Vitro and In Vivo Effect of Chloropromazine, Imipramine and Lithium Chloride on Monoamine Oxidase Activity in Rat Brain Mitochondria
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| Creator |
Nag, Maitreyi
Nandi, Namita |
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| Subject |
Drug Development/Diagnostics & Biotechnology
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| Description |
Chloropromazine (CPZ) and imipramine at a concentration of 1 x 10- 3 M inhibit rat
brain mitochondrial monoamine oxidase activity in vitro by 70 and 55 % respectively,
'while lithium, even at a concentration of 0.05 M, inhibits the activity of this enzyme
'very negligibly (4%). In vivo, these drugs at a dose level of 56 mg CPZ, 76 mg
Jimipramine and 76 mg lithium chloride/Kg body wt., did not cause any observable
'variation from normal in brain mitochondrial monoamine oxidase activity.
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| Publisher |
Kluwer
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| Date |
1987
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/1428/1/Bioscience_Reports%2C_7(_9);_1987[20].pdf
Nag, Maitreyi and Nandi, Namita (1987) In Vitro and In Vivo Effect of Chloropromazine, Imipramine and Lithium Chloride on Monoamine Oxidase Activity in Rat Brain Mitochondria. Bioscience Reports, 7 (9). pp. 701-704. |
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| Relation |
http://dx.doi.org/10.1007/BF01116862
http://www.eprints.iicb.res.in/1428/ |
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