A Facile Synthesis of PEG-Coated Magnetite (Fe3O4) Nanoparticles and Their Prevention of the Reduction of Cytochrome C
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
A Facile Synthesis of PEG-Coated Magnetite (Fe3O4) Nanoparticles
and Their Prevention of the Reduction of Cytochrome C
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| Creator |
Mukhopadhyay, Anindita
Joshi, Nidhi Chattopadhyay, Krishnananda De, Goutam |
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| Subject |
Structural Biology & Bioinformatics
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| Description |
We report here a facile and green synthetic
approach to prepare magnetite (Fe3O4) nanoparticles (NPs)
with magnetic core and polyethylene glycol (PEG) surface
coating. The interaction of the bare and PEG-coated Fe3O4
NPs with cytochrome c (cyt c, an important protein with
direct role in the electron transfer chain) is also reported in
this study. With ultrasonication as the only peptization method
and water as the synthesis medium, this method is easy, fast,
and environmentally benign. The PEG coated NPs are highly
water dispersible and stable. The bare NPs have considerable
magnetism at room temperature; surface modification by PEG
has resulted in softening the magnetization. This approach can very well be applicable to prepare biocompatible, surface-modified
soft magnetic materials, which may offer enormous utility in the field of biomedical research. Detailed characterizations including
XRD, FTIR, TG/DTA, TEM, and VSM of the PEG-coated Fe3O4 NPs were carried out in order to ensure the future applicability
of this method. Although the interaction of bare NPs with cyt c shows reduction of the protein, efficient surface modification by
PEG prevents its reduction
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| Date |
2012
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/1603/1/ACS_APPLIED_MATERIALS_%26_INTERFACES___4(_1)_142%2D149_;2012[112].pdf
Mukhopadhyay, Anindita and Joshi, Nidhi and Chattopadhyay, Krishnananda and De, Goutam (2012) A Facile Synthesis of PEG-Coated Magnetite (Fe3O4) Nanoparticles and Their Prevention of the Reduction of Cytochrome C. ACS Applied Materials & Interfaces, 4 (1). pp. 142-149. |
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| Relation |
http://dx.doi.org/10.1021/am201166m
http://www.eprints.iicb.res.in/1603/ |
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