β-Amyrin acetate and β-Amyrin palmitate as antidyslipidemic agents from Wrightia tomentosa leaves
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
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| Creator |
Maurya, Ranjani
Srivastava, Anuj Shah, Priyanka Siddiqi, M I Rajendran, S M Puri, Anju Yadav, P P |
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| Date |
2012-09-10T06:50:55Z
2012-09-10T06:50:55Z 2012 |
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| Identifier |
Phytomedicine2012, 19(8–9), 682–685
http://hdl.handle.net/123456789/909 |
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| Description |
The ethanolic extract and fractions of Wrightia tomentosa Roem. & Schult (Apocynaceae) leaves were tested in vivo for their antidyslipidemic activity in high fat diet (HFD) induced dyslipidemic hamsters. Activity guided isolation resulted in identification of antidyslipidemic compounds β-AA and β-AP. Compounds β-AA and β-AP decrease the levels of LDL by 36% and 44%, and increase the HDL-C/TC ratio by 49% and 28% respectively at a dose of 10mg/kg. In addition, the isolated compounds β-AA and β-AP showed significant HMGCoA- reductase inhibition which was further established by docking studies.
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| Format |
575303 bytes
application/pdf |
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| Language |
en
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| Relation |
CDRI Communication No. 8220
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| Subject |
Wrightia tomentosa
β-amyrin acetate β-amyrin palmitate Antidyslipidemic activity HMG-CoA reductase inhibitor Cardiovascular disease |
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| Title |
β-Amyrin acetate and β-Amyrin palmitate as antidyslipidemic agents from Wrightia tomentosa leaves
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| Type |
Article
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