Synthesis and evaluation of antithrombotic activity of benzocoumarin amide derivatives
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Sashidhara, K V
Palnati, G R Avula, S R Singh, S Jain, Manish Dikshit, Madhu |
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| Date |
2012-09-11T11:06:01Z
2012-09-11T11:06:01Z 2012 |
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| Identifier |
Bioorganic & Medicinal Chemistry Letters2012, 22 (9), 3115–3121
http://hdl.handle.net/123456789/916 |
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| Description |
A series of novel benzocoumarin amide derivatives have been synthesized and evaluated for their antithrombotic activity in an established model of mouse thrombosis. Compound 8 showed 45% protection, whereas, standard drug aspirin provided 37% protection. Furthermore, compounds 5, 7, and 8 were significantly shown anti-platelets and anti-coagulant action. In that way suggesting its potential as novel antithrombotic agents.
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| Format |
215685 bytes
application/pdf |
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| Language |
en
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| Relation |
CDRI Communication No. 8219
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| Subject |
Pechmann condensation
1,5dihydroxynaphthalene Benzocoumarins amide Antithrombotic activity Bleeding time Anti-platelet Anti-coagulant |
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| Title |
Synthesis and evaluation of antithrombotic activity of benzocoumarin amide derivatives
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| Type |
Article
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