Cascade intermolecular Michael addition-intramolecular azide/ internal alkyne 1,3-dipolar cycloaddition reaction in one-pot
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
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Creator |
Arigela, R K
Mandadapu, A K Sharma, S K Kumar, Brijesh Kundu, Bijoy |
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Date |
2012-09-17T10:41:08Z
2012-09-17T10:41:08Z 2012 |
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Identifier |
Organic Letters, 2012, 14 (7), 1804–1807
http://hdl.handle.net/123456789/918 |
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Description |
A rapid one-pot protocol for the synthesis of indole-based polyheterocycles via a sequential Lewis acid catalyzed intermolecular Michael addition and an intramolecular azide/internal alkyne 1,3-dipolar cycloaddition reaction has been described. The generality of the method has been demonstrated by treating a series of aromatic/aliphatic 2-alkynyl indoles with substituted (E)-1-azido-2-(2-nitrovinyl)benzenes to furnish annulated tetracyclic indolo[2,3-c][1,2,3]triazolo[1,5-a][1]benzazepines in good yields.
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Format |
124693 bytes
application/pdf |
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Language |
en
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Relation |
CDRI Communication No.8217
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Subject |
Polyheterocycles
2-alkynyl Tetracyclic indolo 1,3-dipolar cycloaddition |
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Title |
Cascade intermolecular Michael addition-intramolecular azide/ internal alkyne 1,3-dipolar cycloaddition reaction in one-pot
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Type |
Article
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