A study on neuroinflammatory marker in brain areas of Okadaic acid (ICV) induced memory impaired rats
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Kamat, P K
Tota, S K Rai, Shivika Swarnkar, Supriya Shukla, Rakesh Nath, Chandishwar |
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| Date |
2012-10-03T11:39:31Z
2012-10-03T11:39:31Z 2012 |
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| Identifier |
Life Sciences 2012, 90(19–20), 713–720
http://hdl.handle.net/123456789/919 |
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| Description |
Aims: The aim of the present study is to investigate the status of proinflammatory cytokine in the brain of intracerebroventricular (ICV) okadaic acid (OKA) induced memory impaired rat.
Main methods: OKA (200ng) intracerebroventricular (ICV) was administered in rats. Memory was assessed by Morris water maze test. Biochemical marker of neuroinflammation (TNF-α, IL-β), total nitrite, mRNA (RT PCR) and protein expression (WB) of iNOS and nNOS were estimated in rat brain areas.
Key findings: OKA caused memory-impairment in rats with increased expression of proinflammatory cytokine TNF-α and IL-1β and total nitrite in brain regions hippocampus and cortex. The expression of mRNA and protein of iNOS was increased while; the expressions were decreased in case of nNOS. Pretreatment with antidementic drugs donepezil (5mg/kg, p.o) and memantine (10mg/kg, p.o) for 13 days protected ICV OKA induced memory impairment and changes in level of TNF-α, IL-β, total nitrite and expressions of iNOS and nNOS in OKA treated rat.
Significance: This study suggests that neuroinflammation may play a vital role in OKA induced memory impairment.
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2572714 bytes
application/pdf |
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| Language |
en
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| Relation |
CDRI Communication No. 8234
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| Subject |
Okadaic acid
Memory Neuroinflammation Nitric oxide synthase |
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| Title |
A study on neuroinflammatory marker in brain areas of Okadaic acid (ICV) induced memory impaired rats
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| Type |
Article
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