Anti-Leukemic Activity of Sulfonoquinovosyldiacylglyceride (SQDG): a Constituent of Azadirachta Indica Leaves
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Anti-Leukemic Activity of Sulfonoquinovosyldiacylglyceride (SQDG): a Constituent of Azadirachta Indica Leaves
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| Creator |
Yogesh P, Bharitkar
Bhattacharya, Shamik Das , Tanaya Roy, Moumita Besra, Shila E. Gomes, Aparna Mondal, Nirup B Banerjee, Sukdeb |
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| Subject |
Drug Development/Diagnostics & Biotechnology
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| Description |
The sulfonoquinovosyldiacylglyceride (SQDG)
isolated from the leaves of Azadirachta indica showed
significant anti-leukemic activity in human leukemic cell
lines U937 and K562 with IC50 of 9 lg/ml. SQDG treated
leukemic cells showed chromatin condensation, apoptotic
body formation, and increased caspase 3 production indicating
apoptosis. Cell cycle study revealed that the treated
leukemic cells accumulated in the sub-G1 phase; the cell
cycle was halted in this phase and the DNA content
decreased in other phases.
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| Date |
2012
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/1682/1/SQDG_MCR.pdf
Yogesh P, Bharitkar and Bhattacharya, Shamik and Das , Tanaya and Roy, Moumita and Besra, Shila E. and Gomes, Aparna and Mondal, Nirup B and Banerjee, Sukdeb (2012) Anti-Leukemic Activity of Sulfonoquinovosyldiacylglyceride (SQDG): a Constituent of Azadirachta Indica Leaves. Medicinal Chemistry Research. |
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| Relation |
http://dx.doi.org/10.1007/s00044-012-0001-6
http://www.eprints.iicb.res.in/1682/ |
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