Synthesis of substituted amines and isoindolinones: catalytic reductive amination using abundantly available AlCl3/PMHS
IR@IHBT: CSIR-Institute of Himalayan Bioresource Technology, Palampur
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Title |
Synthesis of substituted amines and isoindolinones: catalytic reductive
amination using abundantly available AlCl3/PMHS
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Creator |
Kumar, Vishal
Sharma, Sushila Sharma, U Singh , Bikram Kumar, Neeraj |
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Subject |
Natural Product Chemistry
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Description |
AlCl3 has been employed for highly chemoselective reductive amination of carbonyl compounds in
ethanol using polymethylhydrosiloxane as an inexpensive, stable and safe reducing agent without an inert
atmosphere. A large range of functional groups such as nitro, carboxylic acid, acetyl, nitrile, halogen,
methoxy, alkene and heterocycles were well tolerated. AlCl3 also catalyzed tandem amination–amidation
of 2-carboxybenzaldehyde with different amines to afford N-substituted isoindolinones. The catalyst can
be recycled at least three times without any significant effect on activity and selectivity.
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Date |
2012
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Type |
Article
PeerReviewed |
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Format |
application/pdf
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Identifier |
http://ihbt.csircentral.net/1234/1/38_Synthesis.pdf
Kumar, Vishal and Sharma, Sushila and Sharma, U and Singh , Bikram and Kumar, Neeraj (2012) Synthesis of substituted amines and isoindolinones: catalytic reductive amination using abundantly available AlCl3/PMHS. Green Chmistry, 14. pp. 3410-3414. |
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Relation |
http://ihbt.csircentral.net/1234/
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