Role of saponins for the anticonvulsant effect of adventitious roots of Ficus religiosa
IR@IHBT: CSIR-Institute of Himalayan Bioresource Technology, Palampur
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| Title |
Role of saponins for the anticonvulsant effect of adventitious
roots of Ficus religiosa
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| Creator |
Singh, Damanpreet
Singh , Bikram Goel, Rajesh Kumar |
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| Subject |
Natural Product Chemistry
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| Description |
Context: The adventitious roots of Ficus religiosa L. (Moraceae) have been extensively used in traditional medicine for
treatment of several disorders, including epilepsy.
Objective: To investigate the possible anticonvulsant effect of the adventitious roots of Ficus religiosa, and to find the
biologically active fraction, to substantiate its traditional use in epilepsy.
Methods: The hydroethanolic extract of adventitious roots (5, 10, and 20 mg/kg; i.p.) of Ficus religiosa and its different
fractions (hexane, chloroform, ethyl acetate, butanol, aqueous, saponins-rich, and saponins-lacking) at a dose
equivalent to 20 mg/kg of the extract were administered 30 min prior to the induction of maximal electroshock
(MES) and pentylenetetrazol (PTZ) convulsions. Duration of tonic hind-limb extension (THLE) and latency to clonic
convulsions were noted in MES and PTZ tests, respectively. Neurotoxicity was assessed using rotarod test.
Results: Treatment with the root extract (5, 10, and 20 mg/kg; i.p.), butanolic (6 mg/kg; i.p.) and saponins-rich fractions
(3.4 mg/kg; i.p.) significantly (p < 0.05) decreased the duration of THLE in MES test, as compared to control. The same
treatment also significantly (p < 0.05) increased the latency to PTZ-induced clonic convulsions in comparison to
control. The other fractions were found to be ineffective. The root extract and its active fractions at their effective
doses showed no neurotoxic effects.
Conclusion: The present study concluded that the hydroethanolic extract of adventitious roots of Ficus religiosa has
anticonvulsant activity. Retention of anticonvulsant effect in the saponins-rich fraction-treated animals indicated the
role of saponins for the activity.
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| Date |
2012
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://ihbt.csircentral.net/1245/1/51_Role_of_saponins_for_the_anticonvulsant_effect_of_adventitious_roots_of_Ficus_religiosa.pdf
Singh, Damanpreet and Singh , Bikram and Goel, Rajesh Kumar (2012) Role of saponins for the anticonvulsant effect of adventitious roots of Ficus religiosa. Journal of Pharmaceutical Biology, 50. pp. 816-822. |
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| Relation |
http://ihbt.csircentral.net/1245/
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