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Preparation and characterization of bio-functionalized iron oxide nanoparticles for biomedical application

IR@NPL: CSIR-National Physical Laboratory, New Delhi


Field	Value

Title	Preparation and characterization of bio-functionalized iron oxide nanoparticles for biomedical application

Creator	Bajaj, Bharat Malhotra, B. D. Choi, Sunju

Subject	Materials Science Physics

Description	Amine modified iron oxide (Fe3O4) nanoparticles were synthesized by thermal decomposition method and were further used to bio-functionalize by grafting of N-hydroxysuccinimide (NHS) ester of folate and ethylenediaminetetraacetate (EDTA). Fe3O4 nanoparticles of ~ 22 nm were confirmed from X-ray diffraction (XRD) and transmission electron microscopy (TEM) studies. FT-IR studies indicated two bands at 1515 cm− 1and 1646 cm− 1, which can be attributed to carboxylic group and the amide linkage respectively, revealing the conjugation of folate with Fe3O4. The conjugation of the chelating agent showed strong C=O stretch and Fe–O vibrations at 1647 and 588 cm− 1 respectively. The value of saturation magnetization for Fe3O4 nanoparticles was found to be 88 emu/g, which further reduced to 18 and 32% upon functionalization with EDTA and NHS ester folate, respectively. These amine modified Fe3O4 nanoparticles can also be functionalized with other bifunctional chelators, such as amino acids based diethylene triamine pentaacetic acid (DTPA), and thus find potential applications in radio-labeling, biosensors and cancer detection, etc

Publisher	Elsevier

Date	2010

Type	Article PeerReviewed

Format	application/pdf

Identifier	http://npl.csircentral.net/283/1/248.pdf Bajaj, Bharat and Malhotra, B. D. and Choi, Sunju (2010) Preparation and characterization of bio-functionalized iron oxide nanoparticles for biomedical application. Thin Solid Films, 519 (3). pp. 1219-1223. ISSN 0040-6090

Relation	http://dx.doi.org/10.1016/j.tsf.2010.08.072 http://npl.csircentral.net/283/