Arsenic Exposure Through Drinking Water Increases the rRsk of Liver and Cardiovascular Diseases in the Population of West Bengal, India
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Arsenic Exposure Through Drinking Water Increases the rRsk of Liver and Cardiovascular Diseases in the Population of West Bengal, India
|
|
| Creator |
Das, Nandana
Paul, Somnath Chatterjee, Debmita Banerjee, Nilanjana Majumder, Niladri S Sarma, Nilendu Sau, Tanmoy J Basu, Santanu Banerjee, Saptarshi Majumder, Papiya Bandyopadhyay, Apurba K States, J Christopher Giri, Ashok K |
|
| Subject |
Molecular & Human Genetics
|
|
| Description |
Background: Arsenic is a natural drinking water contaminant affecting 26 million people in West Bengal, India.
Chronic arsenic exposure causes cancer, cardiovascular disease, liver disease, neuropathies and ocular diseases. The
aims of the present study were to assess bioindicators of hepatocellular injury as indicated by the levels of liver
enzymes, to determine the auto immune status, as indicated by the amounts of anti-nuclear antibodies (ANA) and
anti-dsDNA antibodies in their serum, and to predict cardiovascular risk in the arsenic exposed population.
Methods: Effect of chronic arsenic exposure on liver was determined by liver function tests. Autoimmune status
was measured by measuring ANA and anti-dsDNA in serum. Inflammatory cytokines associated with increased
cardiovascular disease risk, IL6, IL8 and MCP-1 were determined.
Results: Our results indicated that serum levels of bilirubin, alanine transaminase, aspartate transaminase, alkaline
phosphatase and ANA were increased in the arsenic exposed population. Serum levels of IL6 and IL8 also increased
in the arsenic exposed group.
Conclusions: Chronic arsenic exposure causes liver injury, increases the serum levels of autoimmune markers and
imparts increased cardiovascular risk.
Keywords: Arsenic, Antinuclear antibody, Liver function tests, Cytokines
|
|
| Publisher |
BioMed Central
|
|
| Date |
2012
|
|
| Type |
Article
PeerReviewed |
|
| Format |
application/pdf
|
|
| Identifier |
http://www.eprints.iicb.res.in/1716/1/BMC_PUBLIC_HEALTH___12(_639);2012[51].pdf
Das, Nandana and Paul, Somnath and Chatterjee, Debmita and Banerjee, Nilanjana and Majumder, Niladri S and Sarma, Nilendu and Sau, Tanmoy J and Basu, Santanu and Banerjee, Saptarshi and Majumder, Papiya and Bandyopadhyay, Apurba K and States, J Christopher and Giri, Ashok K (2012) Arsenic Exposure Through Drinking Water Increases the rRsk of Liver and Cardiovascular Diseases in the Population of West Bengal, India. BMC Public Health, 12 (639). |
|
| Relation |
http://dx.doi.org/10.1186/1471-2458-12-639
http://www.eprints.iicb.res.in/1716/ |
|