Mode of Action of Pentavalent Antimonials : Specific Inhibition of type I DNA Topoisomerase of Leishmania Donovani
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Mode of Action of Pentavalent Antimonials : Specific Inhibition of type I DNA
Topoisomerase of Leishmania Donovani
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| Creator |
Chakraborty, Asit K
Majumder, Hemanta K |
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| Subject |
Infectious Diseases and Immunology
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| Description |
Sodium stibogluconate and Ureastibamine, two potent
antileishmanial drugs~specifically inhibit the relaxation of
supercoiled plasmid pBR322 catalyzed by DNA topoisomerase I of
Leishmania donovani. Dose dependent inhibition suggests that
the drugs interact with the enzyme rather than the DNA. The
inhibition reported here concerning a type I DNA topoisomerase
demonstrates at least one possible mode of action of these
antileishmanial drugs.
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| Publisher |
Elsevier
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| Date |
1988
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/1755/1/BIOCHEMICAL_AND_BIOPHYSICAL_RESEARCH_COMMUNICATIONS___152_(_2)_605%2D611;1988[41].pdf
Chakraborty, Asit K and Majumder, Hemanta K (1988) Mode of Action of Pentavalent Antimonials : Specific Inhibition of type I DNA Topoisomerase of Leishmania Donovani. Biochemical and Biophysical Research Communications, 152 (2). pp. 605-611. |
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| Relation |
http://dx.doi.org/10.1016/S0006-291X(88)80081-0
http://www.eprints.iicb.res.in/1755/ |
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