Synthesis of novel imbricatolic acid analogues via insertion of N-substituted piperazine at C-15/C-19 positions, displaying glucose uptake stimulation in L6 skeletal muscle cells
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Khan, M F
Kumar, Padam Pandey, Jyotsana Srivastava, A K Tamrakar, A K Maurya, Rakesh |
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| Date |
2013-02-04T08:33:43Z
2013-02-04T08:33:43Z 2012 |
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| Identifier |
Bioorganic & Medicinal Chemistry Letters 2012, 22(14), 4636–4639
http://hdl.handle.net/123456789/986 |
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| Description |
A new class of N-substituted piperazine analogues of imbricatolic acid have been designed and synthesized by using the appropriate synthetic routes in excellent yield. All synthesised compounds were screened for their in vitro glucose uptake stimulatory activity. Among them compounds 4b, 4e, 8b and 8e triggered L6 skeletal muscle cells for glucose uptake at 54.73, 40.79, 40.90 and 39.55% stimulation, respectively. Compound 4b has emerged as important lead compound showing potential antidiabetic activity. Illustration about their synthesis and in vitro glucose uptake activity is described.
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| Format |
199891 bytes
application/pdf |
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| Language |
en
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| Relation |
CDRI Communication No. 8259
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| Subject |
Diterpene
Imbricatolic acid N-Substituted piperazine Glucose uptake |
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| Title |
Synthesis of novel imbricatolic acid analogues via insertion of N-substituted piperazine at C-15/C-19 positions, displaying glucose uptake stimulation in L6 skeletal muscle cells
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| Type |
Article
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