A Chiron Approach to Aminocytitols by Petasis-Borono-Mannich Reaction: Formal Synthesis of (+)-Conduramine E and (-)-Conduramine E
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Ghosal, Partha
Shaw, A K |
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| Date |
2013-02-04T09:02:05Z
2013-02-04T09:02:05Z 2012 |
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| Identifier |
Journal of Organic Chemistry 2012, 77 (17), 7627–7632
http://hdl.handle.net/123456789/991 |
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| Description |
A chiron approach to stereoselective route for the synthesis of aminocytitols from carbohydrates is described. The formal synthesis of (+)-conduramine E and (-)-conduramine E was achieved by utilizing this strategy. The key features of the synthetic strategy include one pot three component Petasis-Borono-Mannich reaction to introduce the syn-ß-amino alcohol functionality of conduramine E and ring closing metathesis to construct its carbocyclic core. The present synthetic approach paves the way for stereoselective synthesis of several conduramines starting from carbohydrates
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| Format |
886642 bytes
application/pdf |
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| Language |
en
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| Relation |
CDRI Communication no. 8302
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| Subject |
Stereoselective
Carbohydrates Aminocytitols |
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| Title |
A Chiron Approach to Aminocytitols by Petasis-Borono-Mannich Reaction: Formal Synthesis of (+)-Conduramine E and (-)-Conduramine E
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| Type |
Article
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