Discovery of amide based fibrates as possible antidyslipidemic and antioxidant agents*
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Sashidhara, K V
Palnati, G R Dodda, R P Sonkar, Ravi Khanna, A K Bhatia, Gitika |
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| Date |
2013-02-04T08:43:52Z
2013-02-04T08:43:52Z 2012 |
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| Identifier |
European Journal of Medicinal Chemistry2012, 57, 302–310
http://hdl.handle.net/123456789/988 |
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| Description |
A novel series of amide based fibrates were synthesized and evaluated for antidyslipidemic activity in triton induced hyperlipidemic rats. Interestingly, the compound 13 produced striking reduction in serum levels of total cholesterol (TC), phospholipids (PL) and triglycerides (TG). In addition, it exhibited improved lipoprotein lipase activity and found to possess moderate radical scavenging potential. The results of the above studies shows that the compounds synthesized on fibrate based pharmacophores might result in identification of new lead for dyslipidemia.
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373925 bytes
application/pdf |
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| Language |
en
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| Relation |
CDRI communication no. 8324
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| Subject |
Amide based fibrates
Antidyslipidemic Triton model Antioxidant activity |
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| Title |
Discovery of amide based fibrates as possible antidyslipidemic and antioxidant agents*
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| Type |
Article
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