Cascade [4+1] annulation via greener nitrogen ylide in water: Synthesis of bicyclic and tricyclic fused dihydrofuran
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Kumar, Atul
Srivastava, Suman Gupta, Garima |
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| Date |
2013-02-05T09:20:13Z
2013-02-05T09:20:13Z 2012 |
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| Identifier |
Green Chemistry2012,14, 3269–3272
http://hdl.handle.net/123456789/992 |
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| Description |
A novel imidazolium ylide activated [4+1] annulation approach is described for the diastereoselective synthesis of bicyclic and tricyclic fused dihydrofurans in water. This cascade annulation presumably proceeds via a Michael reaction triggered zwitterion enolate followed by concomitant intramolecular cylization. The methodology has distinction of being the first report on imidazolium ylide mediated [4+1] annulation in water as a unified greener approach involving in-situ base regeneration system and an alternative to pyridine ylide.
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| Format |
1202055 bytes
application/pdf |
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| Language |
en
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| Relation |
CDRI Communication No. 8335
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| Subject |
Diastereoselective synthesis
Dihydrofurans |
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| Title |
Cascade [4+1] annulation via greener nitrogen ylide in water: Synthesis of bicyclic and tricyclic fused dihydrofuran
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| Type |
Article
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