A natural product inspired hybrid approach towards the synthesis of novel pentamidine based scaffolds as potential anti-parasitic agents
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Tyagi, Vikas
Khan, Shahnawaz Shivahare, Rahul Srivastava, Khushboo Gupta, Suman Kidwai, Saqib Srivastava, Kumkum Puri, S K Chauhan, P M S |
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| Date |
2013-02-05T10:24:14Z
2013-02-05T10:24:14Z 2013 |
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| Identifier |
Bioorganic & Medicinal Chemistry Letters 2013, 23(1), 291–296
http://hdl.handle.net/123456789/996 |
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| Description |
A natural product inspired molecular hybridization approach led us to a series of novel pentamidine based pyrimidine and chalcone scaffolds. All the hybrids were evaluated for their anti-leishmanial potential. Most of the screened compounds have showed significant in vitro anti-leishmanial activity with less cytotoxicity in comparison to the standard drugs (pentamidine, sodium stibogluconate, and miltefosine). Additionally, anti-malarial screening of these compounds was also done and four compounds have shown superior activity against chloroquine resistance strain (K1) of Plasmodium falciparum.
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785252 bytes
application/pdf |
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| Language |
en
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| Relation |
CDRI Communication No. 8343
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| Subject |
Pyrimidine
Chalcone Pentamidine Anti-leishmanial activity Anti-malarial activity |
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| Title |
A natural product inspired hybrid approach towards the synthesis of novel pentamidine based scaffolds as potential anti-parasitic agents
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| Type |
Article
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