Unusual in Vivo Turnover of Transfer RNA in Vibrio Cholerae
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Unusual in Vivo Turnover of Transfer RNA in Vibrio Cholerae
|
|
| Creator |
Mukhopadhyay, Partha
Gangopadhyay, Tapan Ghosh, Ranajit K |
|
| Subject |
Infectious Diseases and Immunology
|
|
| Description |
Two lines of evidence suggest that, unlike in other organisms, the transfer
RNAs of Vibrio cholerae undergo rapid turnover in vivo. Firstly, the tRNA
content of V. cholerae cells treated with rifampicin (an inhibitor of initiation
of RNA synthesis) decreased rapidly and continuously. Secondly, the newly
synthesized tRNAs were rapidly degraded even under normal conditions of
growth; the average half life of tRNA was 11.8 min. The degradation is
mediated by an enzyme(s), present in V. cholerae cytoplasm, that apparently
degrades tRNA completely. Rapid turnover is balanced by an enhanced rate of
tRNA biogenesis, which was calculated to be 2.5 times higher than that in
Escherichia coli
|
|
| Date |
1994
|
|
| Type |
Article
PeerReviewed |
|
| Format |
application/pdf
|
|
| Identifier |
http://www.eprints.iicb.res.in/1772/1/MICROBIOLOGY%2DUK__140___1775%2D1779___Part_Part_71994[34].pdf
Mukhopadhyay, Partha and Gangopadhyay, Tapan and Ghosh, Ranajit K (1994) Unusual in Vivo Turnover of Transfer RNA in Vibrio Cholerae. Microbiology UK, 140. pp. 1775-1779. |
|
| Relation |
http://dx.doi.org/
http://www.eprints.iicb.res.in/1772/ |
|