CSIR Central

Involvement of Gamma-Aminobutyric Acid in the Stimulatory Effect of Metoclopramide on Gastrointestinal Motility

IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata


Field	Value

Title	Involvement of Gamma-Aminobutyric Acid in the Stimulatory Effect of Metoclopramide on Gastrointestinal Motility

Creator	Chaudhuri, Lalima Ganguly, D K

Subject	Drug Development/Diagnostics & Biotechnology

Description	The involvement of gam ma-aminobut yric acid ( GABA ) in the mechanism of action of metoclopramide (MCP) on gastrointestinal (GI) tract was investigated employing guinea-pig myenteric plexus longitudinal muscle preparations. MCP induced a concentration dependent enhancement of e l e c t r i c a l l y induced twitch responses of the myenteric plexus and this effect was further i n t e n s i f i e d by arecaidine and L-2, 4-diaminobutyric acid (L-DABA; GABA uptake i n h i b i t o r s ) and ethylenediamine (EDA;GABA releasing agent). The f a c i l i t a t o r y effect of MCP was reduced by 3-mercaptopropionic acid (3-MPA; GABA synthesis and release i n h i b i t o r ) and after GABA desensitization but remained unchanged after bicuculline methiodide, a specific GABA receptor antagonist. The MCP induced contraction of the unstimulated preparation was also reduced after GABA desensitization and EDA without affecting responses to exogenous acetylcholine (ACh). The study indicates that GABA plays a role in the f a c i l i t a t o r y effect of MCP on both stimulated and unstimulated preparations of guineapig myenteric plexus.

Publisher	Elsevier

Date	1994

Type	Article PeerReviewed

Format	application/pdf

Identifier	http://www.eprints.iicb.res.in/1774/1/LIFE_SCIENCES___54__(_4)_253%2D259;1994[75].pdf Chaudhuri, Lalima and Ganguly, D K (1994) Involvement of Gamma-Aminobutyric Acid in the Stimulatory Effect of Metoclopramide on Gastrointestinal Motility. Life Sciences, 54 (4). pp. 253-259.

Relation	http://dx.doi.org/10.1016/0024-3205(94)00814-0 http://www.eprints.iicb.res.in/1774/