Decrease in b-Adrenergic Receptors of Cerebral Astrocytes in Hypothyroid Rat Brain
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Decrease in b-Adrenergic Receptors of Cerebral Astrocytes in Hypothyroid Rat Brain
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| Creator |
Das, Sumantra
Paul, Surojit |
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| Subject |
Cell Biology & Physiology
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| Description |
Studies on the binding of 3H-dihydroalprenolol (3H-DHA) to astrocytes
from cerebra of normal and hypothyroid rats show that hypothyroidism
results in a decline in the ~-adrenergic receptors.
Ontogenic studies indicated that in normal, euthyroid rats, the
maximum binding capacity (Bmax) for 3H-DHA progressively increased
with age while the affinity (Kd) remained unaltered. In astrocytes
prepared from hypothyroid rats, total number of binding
sites for 3H-DHA also increased with age, however, at a given age,
the number was significantly lower than that for corresponding
euthyroid animals while the affinity for 3H-DHA remained unaffected.
Correspondingly, primary cultures of astrocytes from normal
and hypothyroid brain when maintained in TH-deficient serum,
display a similar reduction of 3H-DHA binding. In the case of
astrocytes from hypothyroid brain cultured in TH-dfficient serum,
the decline can be largely restored by supplementing with normal
serum. Results suggest that thyroid hormones (TH) directly or
indirectly regulates the level of ~-adrenergic receptors in
astrocytes from developing rat brain.
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| Publisher |
Elsevier
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| Date |
1994
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/1776/1/LIFE_SCIENCES___54(_9)_621%2D629;1994[76].pdf
Das, Sumantra and Paul, Surojit (1994) Decrease in b-Adrenergic Receptors of Cerebral Astrocytes in Hypothyroid Rat Brain. Life Sciences, 54 (9). pp. 621-629. |
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| Relation |
http://dx.doi.org/10.1016/0024-3205(94)00868-X
http://www.eprints.iicb.res.in/1776/ |
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