Antileishmanial Activity of Hamycin : A Polyene Antibiotic
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Antileishmanial Activity of Hamycin : A Polyene Antibiotic
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| Creator |
Sarkar, Sibaji
Mukherjee, Tanmoy Patra, Parameswar Bhaduri, Amar Nath |
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| Subject |
Infectious Diseases and Immunology
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| Description |
Hamycin, a polyene antibiotic, now in extensive use in the
treatment of candidiasis and otomycosis, is found to be remarkably effective
in killing Leishmania donovani promastigotes in a liquid medium
at a concentration of 0.2 ~g/ml. The glucose stimulated respiration and
the uptake of 2-deoxy-D[U-14 C] -glucose was inhibited in cells treated
with the drug at a growth inhibitory concentration. An immediate release
of isotopic glucose from preloaded cells could be demonstrated after
exposure to hamycin. All the above effects could be effectively prevented
in the presence of ergosterol. The primary site of action of hamycin
on L. donovani promastigote cells appears to be membrane sterols that
resu-i-t in the loss of the permeability barrier to small metabolites.
The lower minimum inhibitory concentration of hamycin compared to other
established drugs warrants further study in the context of increasing
reports of clinical resistance to pentavalent antimonials.
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| Publisher |
Elsevier
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| Date |
1992
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/1786/1/BIOCHEMICAL_AND_BIOPHYSICAL_RESEARCH_COMMUNICATIONS__182___(_1)_86%2D91;1992[57].pdf
Sarkar, Sibaji and Mukherjee, Tanmoy and Patra, Parameswar and Bhaduri, Amar Nath (1992) Antileishmanial Activity of Hamycin : A Polyene Antibiotic. Biochemical and Biophysical Research Communications, 182 (1). pp. 86-91. |
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| Relation |
http://dx.doi.org/10.1016/S0006-291X(05)80115-9
http://www.eprints.iicb.res.in/1786/ |
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