Effect of Bioamines on Uptake of Promastigotes of Leishmania Donovani by Hamster Peritoneal Macrophages
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Effect of Bioamines on Uptake of Promastigotes of Leishmania Donovani by Hamster Peritoneal Macrophages
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| Creator |
Mitra, Smita
Ghosh, Lagnajita Chakrabarty, Pampa Biswas, Madhumita Bhattacharyya, F. Kathlene Ghosh, D K |
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| Subject |
Drug Development/Diagnostics & Biotechnology
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| Description |
Epinephrine and norepinephrine inhibit attachment of Leishmania donovani
promastigotes to cultured hamster peritoneal macrophages. The inhibition was significant at catecholamine concentrations of and 1 0 - 5 M and occurred when they were added to the cell mixtures, or after pre-treatment of either macrophages or parasites. Inhibition of attachment after pre-treatment was less marked than when the catecholamines were added to parasite-cell mixtures. Similar results were obtained with dibutyryl cyclic AMP, cholera toxin, theophylline, and cadaverine which raise intracellular cyclic AMP (CAMP). Pretreatment of parasites or macrophages with the bioamines elevated the intracellular cAMP concentration. It is suggested that the inhibitory effect on the host-parasite interaction is mediated through CAMP
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| Publisher |
Society for General Microbiology
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| Date |
1992
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/1795/1/JOURNAL_OF_MEDICAL_MICROBIOLOGY___36_(_4)_283%2D287;1992[43].pdf
Mitra, Smita and Ghosh, Lagnajita and Chakrabarty, Pampa and Biswas, Madhumita and Bhattacharyya, F. Kathlene and Ghosh, D K (1992) Effect of Bioamines on Uptake of Promastigotes of Leishmania Donovani by Hamster Peritoneal Macrophages. Journal of Medical Microbiology, 36 (4). pp. 283-287. ISSN 0022-2615 |
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| Relation |
http://dx.doi.org/10.1099/00222615-36-4-283
http://www.eprints.iicb.res.in/1795/ |
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