Tandem aldehyde-alkyne-amine coupling/cycloisomerization: A new synthesis of coumarins.
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Reddy, M S
Thirupathi, Nuligonda Haribabu, Madala |
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| Date |
2013-03-06T06:03:13Z
2013-03-06T06:03:13Z 2013 |
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| Identifier |
Beilstein Journal of Organic Chemistry, 2013, 9, 180–184
http://hdl.handle.net/123456789/1004 |
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| Description |
Cu catalyzed A3 coupling of ethoxyacetylene, pyrrolidine and salycilaldehydes led to a concomitant cycloisomerization followed by hydrolysis of the resultant vinyl ether to afford coumarins in a cascade process. The reaction proceeded through exclusive 6-endo-dig cyclization and is compatible with halo and keto groups giving coumarins in good to moderate yields.
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| Format |
188273 bytes
application/pdf |
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| Language |
en
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| Relation |
CDRI Communication No. 8371
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| Subject |
A3 coupling
Cycloisomerization Transition metal catalysts Cooperative catalysis Coumarin Synthesis |
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| Title |
Tandem aldehyde-alkyne-amine coupling/cycloisomerization: A new synthesis of coumarins.
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| Type |
Article
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