Synthesis and in Vitro Study of Antibacterial, Antifungal Activities of some Novel Bisquinolines
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Synthesis and in Vitro Study of Antibacterial, Antifungal Activities
of some Novel Bisquinolines
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| Creator |
Sahu, Krishnendu B
Ghosh, Soma Banerjee , Maitreyee Maity, Arindam Mondal, Shyamal Paira , Rupankar Saha , Pritam Naskar, Subhendu Hazra , Abhijit Banerjee, Sukdeb Samanta, Amalesh Mondal, Nirup B |
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| Subject |
Chemistry
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| Description |
Efficient syntheses of a series of novel bisquinolines
have been accomplished from8-hydroxy quinolines under
phase transfer catalyzed conditions using tetrabutylamoniumbromide
as phase transfer catalyst. In vitro antibacterial and antifungal
study of the synthesized analogues revealed six of them to
show significant antibacterial and four to show significant antifungal
activity. Among them 3c and 6c show most significant
antibacterial activities with minimum inhibitory concentration
value 32 lg/mL against four bacterial strains. Ultra structural
studies of the microbes treated with 6c demonstrated deformation
of cell wall and cell agglomeration. The bisquinolines
exhibiting bacteriostatic or fungistatic activity may be developed
as newer antimicrobial agents.
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| Date |
2013
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/1814/1/MEDICINAL_CHEMISTRY_RESEARCH___22__(_1)_94%2D104_2003[19].pdf
Sahu, Krishnendu B and Ghosh, Soma and Banerjee , Maitreyee and Maity, Arindam and Mondal, Shyamal and Paira , Rupankar and Saha , Pritam and Naskar, Subhendu and Hazra , Abhijit and Banerjee, Sukdeb and Samanta, Amalesh and Mondal, Nirup B (2013) Synthesis and in Vitro Study of Antibacterial, Antifungal Activities of some Novel Bisquinolines. Medicinal Chemistry Research, 22 (1). pp. 94-104. |
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| Relation |
http://dx.doi.org/10.1007/s00044-012-0011-4
http://www.eprints.iicb.res.in/1814/ |
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