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Efficient Synthesis of Imidazole-Fused Benzodiazepines Using Palladium- Catalyzed Intramolecular C–N Bond Formation Reaction

IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata

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Title Efficient Synthesis of Imidazole-Fused Benzodiazepines Using Palladium- Catalyzed Intramolecular C–N Bond Formation Reaction
 
Creator Maitra, Sudipta
Darira, Heena
Chattopadhyay, Partha
 
Subject Chemistry
 
Description An efficient three-step synthetic route to imidazolefused benzodiazepines from imidazole-2-carbaldehyde is described. Application of intramolecular Buchwald–Hartwig cycloamination reaction in the final step is shown to be a convenient method for the synthesis of fused seven-membered diazacycles. The reactions proceeded smoothly with both aliphatic and aromatic amines.
 
Date 2013
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1823/1/SYNTHESIS%2DSTUTTGART___45(_1)_85%2D92;2013[17].pdf
Maitra, Sudipta and Darira, Heena and Chattopadhyay, Partha (2013) Efficient Synthesis of Imidazole-Fused Benzodiazepines Using Palladium- Catalyzed Intramolecular C–N Bond Formation Reaction. Synthesis, 45 (1). pp. 85-92.
 
Relation http://dx.doi.org/10.1055/s-0032-1316828
http://www.eprints.iicb.res.in/1823/