Regioselective synthesis of densely functionalized, enantiopure, sugar-pyrazole hybrids as potential scaffolds for drug discovery
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Saquib, Mohammad
Husain, Irfan Kant, Ruchir Meena, Sanjeev Gauniyal, H M Sinha, Sudhir Maulik, P R Shaw, A K |
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| Date |
2013-04-04T11:08:43Z
2013-04-04T11:08:43Z 2013 |
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| Identifier |
RSC Advances, 2013, 3, 4526-4530
http://hdl.handle.net/123456789/1040 |
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| Description |
A versatile new synthetic strategy utilizing MBH chemistry for the assembly of highly functionalized enantiopure sugar-pyrazole hybrid molecules with multiple sites for structural diversification and non-flat skeleton as potential drug scaffolds is reported. Four representative molecules were screened for in vitro anti-cancer activity wherein three of them were found to exhibit good anti-cancer activity.
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| Format |
364385 bytes
application/pdf |
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| Language |
en
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| Relation |
CDRI Communication No. 8292
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| Subject |
MBH
Sugar-pyrazole Non-flat skeleton |
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| Title |
Regioselective synthesis of densely functionalized, enantiopure, sugar-pyrazole hybrids as potential scaffolds for drug discovery
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| Type |
Article
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