Synthesis of Perspicamide A and Related Diverse Analogues: Their Bio-evaluation as Potent Antileishmanial Agents
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Pandey, A K
Sharma, Rashmi Shivahare, Rahul Arora, Ashish Rastogi, Neeraj Gupta, Suman Chauhan, P M S |
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| Date |
2013-04-04T11:04:06Z
2013-04-04T11:04:06Z 2013 |
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| Identifier |
Journal of Organic Chemistry, 2013, 78 (4), 1534–1546
http://hdl.handle.net/123456789/1039 |
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| Description |
The first protocol for the synthesis of perspicamide A and related diverse analogues has been developed from economical and readily available starting materials. Furthermore, a few synthesized analogues 24a, 24b, 24c, 24d and 24l exhibited potent activity against Leishmania donovani with IC50 values ranging from 3.75 to 10.37 µM and a selectivity index (SI) ranging from 9.58 to 53.12 which is better compared to the standard drug Miltefosine (IC50 12.4 µM and SI 4.1).
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| Format |
320531 bytes
application/pdf |
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| Language |
en
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| Relation |
CDRI communication no. 8378
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| Subject |
Perspicamide A
Leishmania donovani Standard drug Miltefosine |
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| Title |
Synthesis of Perspicamide A and Related Diverse Analogues: Their Bio-evaluation as Potent Antileishmanial Agents
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| Type |
Article
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