An Approach for the Identification of Targets Specific to Bone Metastasis Using Cancer Genes Interactome and Gene Ontology Analysis
IR@IHBT: CSIR-Institute of Himalayan Bioresource Technology, Palampur
View Archive Info| Field | Value | |
| Title |
An Approach for the Identification of Targets Specific to
Bone Metastasis Using Cancer Genes Interactome and
Gene Ontology Analysis
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| Creator |
Vashisht, Shikha
Bagler, Ganesh |
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| Subject |
Bioinformatics
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| Description |
Metastasis is one of the most enigmatic aspects of cancer pathogenesis and is a major cause of cancer-associated mortality.
Secondary bone cancer (SBC) is a complex disease caused by metastasis of tumor cells from their primary site and is
characterized by intricate interplay of molecular interactions. Identification of targets for multifactorial diseases such as SBC,
the most frequent complication of breast and prostate cancers, is a challenge. Towards achieving our aim of identification of
targets specific to SBC, we constructed a ‘Cancer Genes Network’, a representative protein interactome of cancer genes.
Using graph theoretical methods, we obtained a set of key genes that are relevant for generic mechanisms of cancers and
have a role in biological essentiality. We also compiled a curated dataset of 391 SBC genes from published literature which
serves as a basis of ontological correlates of secondary bone cancer. Building on these results, we implement a strategy
based on generic cancer genes, SBC genes and gene ontology enrichment method, to obtain a set of targets that are
specific to bone metastasis. Through this study, we present an approach for probing one of the major complications in
cancers, namely, metastasis. The results on genes that play generic roles in cancer phenotype, obtained by network analysis
of ‘Cancer Genes Network’, have broader implications in understanding the role of molecular regulators in mechanisms of
cancers. Specifically, our study provides a set of potential targets that are of ontological and regulatory relevance to
secondary bone cancer.
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| Date |
2012
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://ihbt.csircentral.net/1336/1/128_An_Approach.pdf
Vashisht, Shikha and Bagler, Ganesh (2012) An Approach for the Identification of Targets Specific to Bone Metastasis Using Cancer Genes Interactome and Gene Ontology Analysis. Journal of PLOS ONE, 7 (11). pp. 1-17. |
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| Relation |
http://ihbt.csircentral.net/1336/
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