Genome-wide analysis reveals distinct patterns of epigenetic features in long non-coding RNA loci
IR@IGIB: CSIR-Institute of Genomics & Integrative Biology, New Delhi
View Archive Info| Field | Value | |
| Title |
Genome-wide analysis reveals distinct patterns
of epigenetic features in long non-coding RNA loci
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| Creator |
Sati, Satish
Ghosh, Saurav Jain, Vaibhav Scaria, Vinod Sengupta, Shantanu |
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| Subject |
CH1 Chemical Biology
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| Description |
ABSTRACT
A major fraction of the transcriptome of higher or-
ganisms comprised an extensive repertoire of long
non-coding RNA (lncRNA) which express in a cell
type and development stage-specific manner.
While lncRNAs are a proven component of epigenetic
gene expression modulation, epigenetic regulation
of lncRNA itself remains poorly understood.
Here we have analysed pan-genomic DNA methylation
and histone modification marks (H3K4me3,
H3K9me3, H3K27me3 and H3K36me3) associated
with transcription start site (TSS) of lncRNA in four
different cell types and three different tissue types
representing various cellular stages. We observe
that histone marks associated with active transcription
H3K4me3 and H3K36me3 along with the
repressive histone mark H3K27me3 have similar distribution
pattern around TSS irrespective of cell
types. Also, the density of these marks correlates
well with expression of protein-coding and lncRNA
genes. In contrast, the lncRNA genes harbour higher
methylation density around TSS than protein-coding
genes regardless of their expression status.
Furthermore, we found that DNA methylation along
with the other repressive histone mark H3K9me3
does not seem to play a role in lncRNA expression.
Thus, our observation suggests that epigenetic
regulation of lncRNA shares common features with
mRNA except the role of DNA methylation which is
markedly dissimilar.
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| Date |
2012
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| Type |
Article
NonPeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://openaccess.igib.res.in/152/1/Nucl.%20Acids%20Res.%2D2012%2DSati%2Dnar_gks776.pdf
Sati, Satish and Ghosh, Saurav and Jain, Vaibhav and Scaria, Vinod and Sengupta, Shantanu (2012) Genome-wide analysis reveals distinct patterns of epigenetic features in long non-coding RNA loci. Genome-wide analysis reveals distinct patterns of epigenetic features in long non-coding RNA loci, 1 (14). pp. 10-1093. |
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| Relation |
http://openaccess.igib.res.in/152/
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