Antibacterial activities of gold and silver nanoparticles against Escherichia coli and bacillus Calmette-Guérin
IR@CECRI: CSIR-Central Electrochemical Research Institute, Karaikudi
View Archive Info| Field | Value | |
| Title |
Antibacterial activities of gold and silver
nanoparticles against Escherichia coli and bacillus
Calmette-Guérin
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| Creator |
Zhou, Y.
Kong, Y. Kundu, S. Cirillo, J.D. Liang, H. |
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| Subject |
Electrobiology
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| Description |
Background: Diseases such as tuberculosis (TB) have always had a large impact on human health. Bacillus
Calmette-Guérin (BCG) is used as a surrogate for TB during the development of anti-TB drugs. Nanoparticles (NPs)
have attracted great interest in drug development. The purpose of this study was to examine the potential of NPs
as anti-TB compounds by studying the interacting mechanisms between NPs and bacteria.
Results: We investigated effects of gold and silver NPs on BCG and Escherichia coli. Experimentally, particle size and
shape were characterized using transmission electron microscopy (TEM). Different concentrations of NPs were
applied in bacterial culture. The growth of E. coli was monitored through colony forming units (CFU). The
mechanism of interaction between NPs and bacteria was analyzed through bacterial thin sections followed by TEM
and scanning electron microscopy. Antibacterial effects on BCG were observed by recording fluorescent protein
expression levels.
Conclusions: The results suggest NPs have potential applications as anti-TB compounds. The antibacterial effects
and mechanism of action for NPs were dependent upon composition and surface modifications.
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| Date |
2012
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://cecri.csircentral.net/3013/1/044-2012.pdf
Zhou, Y. and Kong, Y. and Kundu, S. and Cirillo, J.D. and Liang, H. (2012) Antibacterial activities of gold and silver nanoparticles against Escherichia coli and bacillus Calmette-Guérin. Journal of Nanobiotechnology, 10 (19). pp. 1-9. |
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| Relation |
http://cecri.csircentral.net/3013/
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