Effects of interferons and interleukin 2 on natural killing of cytomegalovirus-infected fibroblasts
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Effects of interferons and interleukin 2 on
natural killing of cytomegalovirus-infected fibroblasts
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| Creator |
Bandyopadhyay, Santu
Miller, D S Matsumoto-Kobayashi, M Clark, S C Starr, S E |
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| Subject |
Infectious Diseases and Immunology
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| Description |
The ability of nonadherent peripheral blood mononuclear cells of normal individuals to
lyse noninfected and cytomegalovirus (CMV)-infected human fibroblasts was enhanced
by preincubation with recombinant human alpha interferon (LX-rIFN) or beta (f3-rIFN). In
contrast, recombinant human gamma IFN (y-rIFN) augmented natural killing (NK)
against both targets relatively poorly. Recombinant or natural human interleukin 2(IL-2)
also augmented NK against noninfected and CMV-infected targets. Augmentation ofNK
by IFN or IL-2 could be blocked by the addition of corresponding antisera. IL-2-
enhanced NK against CMV-infected targets was usually independent of o-IFN production
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| Date |
1987
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/1898/1/%2CClin._exp._Immunol.__67%2C_372%2D382;1987.pdf
Bandyopadhyay, Santu and Miller, D S and Matsumoto-Kobayashi, M and Clark, S C and Starr, S E (1987) Effects of interferons and interleukin 2 on natural killing of cytomegalovirus-infected fibroblasts. Clinical experimental Immunology, 67. pp. 372-382. |
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| Relation |
http://www.eprints.iicb.res.in/1898/
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