Natural killing of fibroblasts infected with low-passage clinical isolates of human cytomegalovirus
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Natural killing of fibroblasts infected with low-passage
clinical isolates of human cytomegalovirus
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| Creator |
Bandyopadhyay, Santu
Hee oh, , Sung Michelson, Susan Miller, Deborah S |
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| Subject |
Infectious Diseases and Immunology
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| Description |
Fibroblasts infected with most low-passage clinical isolates of human cytomegalovirus (CMV) were
as susceptible to lysis by human natural killer (NK) cells as high passage AD-169-infected fibroblasts.
NK lysis occurred despite the absence of detectable CMV-specific late membrane antigen(s) on the
majority ofthe target cells infected with most of the low passage strains. The magnitude ofNK lysis of
different CMV-infected target cells did not correlate with their ability to induce IFN-a. NK cellmediated
lysis of cells infected with low-passage clinical isolates ofCMV required both NK cells and
HLA-DR+ accessory cells, as previously shown for AD-169-infected target cells.
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| Date |
1988
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/1904/1/Clin._exp._Immunol.__73%2C_11%2D16;1988.pdf
Bandyopadhyay, Santu and Hee oh, , Sung and Michelson, Susan and Miller, Deborah S (1988) Natural killing of fibroblasts infected with low-passage clinical isolates of human cytomegalovirus. Clinical experimental Immunology, 73. pp. 11-16. |
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| Relation |
http://www.eprints.iicb.res.in/1904/
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