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Dendritic cells and IFN-a-producing cells are two functionally distinct non-B,non-monocytic HLA-DR+ cell subsets in human peripheral blood

IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata


Field	Value

Title	Dendritic cells and IFN-a-producing cells are two functionally distinct non-B,non-monocytic HLA-DR+ cell subsets in human peripheral blood

Creator	Chehimi, J Kawashima, H Miller, D S Starr, S E Trinchierit , G Perussia, B Bandyopadhyay, Santu

Subject	Infectious Diseases and Immunology

Description	At least two distinct HLA-DR+ cell subsets lacking surface markers specific for B cells, monocytes or other known lineages are present in human peripheral blood. One subset is non-adherent to plastic, produces interferon-alpha (IFN-a) when incubated with cytomegalovirus-infected target cells and provides an accessory function required for natural killer (NK) cell-mediated lysis of such cells. These non-adherent HLA-DR+ cells express the surface antigen recognized by antibody anti-D44 and do not stimulate mixed leucocyte reaction (MLR). The other HLA-DR+ cell subset is loosely adherent to plastic, produces only minimal levels of IFN-a when incubated with cytomegalovirus-infected target cells and does not provide the accessory function required for NK cell-mediated lysis of such cells. These HLA-DR+ cells stimulate a strong MLR, do not express D44 antigen and meet the criteria of dendritic cells (DC) morphologically and functionally

Publisher	Blackwell Publishing

Date	1989

Type	Article PeerReviewed

Format	application/pdf

Identifier	http://www.eprints.iicb.res.in/1906/1/Immunology%2C__68%2C_486%2D490;1989.pdf Chehimi, J and Kawashima, H and Miller, D S and Starr, S E and Trinchierit , G and Perussia, B and Bandyopadhyay, Santu (1989) Dendritic cells and IFN-a-producing cells are two functionally distinct non-B,non-monocytic HLA-DR+ cell subsets in human peripheral blood. Immunology, 68. pp. 486-490.

Relation	http://www.eprints.iicb.res.in/1906/